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According to the observations of tadalafil, antibody formation is more intense in severe diabetes and microangiopathy, as well as with the introduction of drugs of prolonged action. This chapter discusses the treatment of allergic reactions to less purified insulin preparations. There are local (local) and general (generalized) allergic reactions to insulin.

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A local allergic reaction to insulin occurs at the site of cialis injection, more often after 1-2 weeks from the start of treatment, usually acutely (within 1 hour after injection, rarely after 6-24 hours).

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It is expressed in hyperemia and swelling of a skin area with a diameter of 1-5 cm, accompanied by burning, itching or pain. Sometimes the reaction is manifested by a papular rash, an infiltrate in the subcutaneous tissue at the injection site, very rarely there is aseptic tissue necrosis of the type of the Arthus phenomenon. In the genesis of allergic reactions of the immediate type, circulating antibodies of the IgE and IgG classes play a leading role.

The propensity to form antibodies in response to insulin administration is determined at the genetic level, therefore, there is a different tolerance of the same drugs in different patients. According to A.V. Dreval (1974), a more massive formation of antibodies should be expected in patients with severe diabetes complicated by microangiopathy and when using prolonged forms of insulin.